Gaynes BN, Gavin N, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G et al. Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid Rep Technol Assess (Summ). 2005:1–8. https://doi.org/10.1037/e439372005-001.
Lee AM, Lam SK, Sze Mun Lau SM, Chong CS, Chui HW, Fong DY. Prevalence, course, and risk factors for antenatal anxiety and depression. Obstet Gynecol. 2007;110:1102–12.
Google Scholar
Davenport MH, Meyer S, Meah VL, Strynadka MC, Khurana R. Moms Are Not OK: COVID-19 and Maternal Mental Health. Front Glob Womens Health. 2020;1:1.
Google Scholar
Trost SLBJ, Njie F, et al. Pregnancy-related deaths: data from maternal mortality review committees in 36 US States, 2017-2019. Centers for Disease Control and Prevention, US Department of Health and Human Services;2022.
House W Blueprint for addressing the maternal health crisis. 2022.
Brody D, Gu Q Antidepressant use among adults: United States, 2015–2018. NCHS Data Brief, no 377 Hyattsville, MD: National Center for Health Statistics 2020.
Anderson KN, Lind JN, Simeone RM, Bobo WV, Mitchell AA, Riehle-Colarusso T, et al. Maternal use of specific antidepressant medications during early pregnancy and the risk of selected birth defects. JAMA Psychiatry. 2020;77:1246–55.
Google Scholar
Cornet MC, Wu YW, Forquer H, Avalos LA, Sriram A, Scheffler AW, et al. Maternal treatment with selective serotonin reuptake inhibitors during pregnancy and delayed neonatal adaptation: a population-based cohort study. Arch Dis Child Fetal Neonatal Ed. 2024;109:294–300.
Google Scholar
Vignato JA, Gumusoglu SB, Davis HA, Scroggins SM, Hamilton WS, Brandt DS et al. Selective serotonin reuptake inhibitor use in pregnancy and protective mechanisms in preeclampsia. Reprod Sci. 2023;30:701–12.
Obermanns J, Flasbeck V, Steinmann S, Juckel G, Emons B. Investigation of the serotonergic activity and the serotonin content in serum and platelet, and the possible role of the serotonin transporter in patients with depression. Behav Sci (Basel). 2022;12:178.
Google Scholar
Gumusoglu SB, Schickling BM, Vignato JA, Santillan DA, Santillan MK. Selective serotonin reuptake inhibitors and preeclampsia: a quality assessment and meta-analysis. Pregnancy Hypertens. 2022;30:36–43.
Google Scholar
Hou R, Ye G, Liu Y, Chen X, Pan M, Zhu F, et al. Effects of SSRIs on peripheral inflammatory cytokines in patients with Generalized Anxiety Disorder. Brain Behav Immun. 2019;81:105–10.
Google Scholar
Golyszny M, Obuchowicz E. Are neuropeptides relevant for the mechanism of action of SSRIs? Neuropeptides. 2019;75:1–17.
Google Scholar
Więdłocha M, Marcinowicz P, Krupa R, Janoska-Jaździk M, Janus M, Dębowska W, et al. Effect of antidepressant treatment on peripheral inflammation markers – A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2018;80:217–26.
Google Scholar
Lopez-Vilchez I, Diaz-Ricart M, Navarro V, Torramade S, Zamorano-Leon J, Lopez-Farre A, et al. Endothelial damage in major depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model. Transl Psychiatry. 2016;6:e886.
Google Scholar
Gur TL, Palkar AV, Rajasekera T, Allen J, Niraula A, Godbout J, et al. Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring. Behav Brain Res. 2019;359:886–94.
Google Scholar
Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2022;28:3243–56.
Google Scholar
Molenaar NM, Kamperman AM, Boyce P, Bergink V. Guidelines on treatment of perinatal depression with antidepressants: an international review. Aust N Z J Psychiatry. 2018;52:320–7.
Google Scholar
Fischer Fumeaux CJ, Morisod Harari M, Weisskopf E, Eap CB, Epiney M, Vial Y, et al. Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence – an update. Expert Opin Drug Saf. 2019;18:949–63.
Google Scholar
Dubovicky M, Belovicova K, Csatlosova K, Bogi E. Risks of using SSRI / SNRI antidepressants during pregnancy and lactation. Interdiscip Toxicol. 2017;10:30–4.
Google Scholar
Hviid A, Melbye M, Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med. 2013;369:2406–15.
Google Scholar
Grzeskowiak LE, Gilbert AL, Morrison JL. Long term impact of prenatal exposure to SSRIs on growth and body weight in childhood: evidence from animal and human studies. Reprod Toxicol. 2012;34:101–9.
Google Scholar
van Geffen EC, Hermsen JH, Heerdink ER, Egberts AC, Verbeek-Heida PM, van Hulten R. The decision to continue or discontinue treatment: experiences and beliefs of users of selective serotonin-reuptake inhibitors in the initial months–a qualitative study. Res Social Adm Pharm. 2011;7:134–50.
Google Scholar
Ratajczak P, Martynski J, Zieba JK, Swilo K, Kopciuch D, Paczkowska A, et al. Comparative efficacy of animal depression models and antidepressant treatment: a systematic review and meta-analysis. Pharmaceutics. 2024;16:1144.
Google Scholar
Normann C, Frase S, Haug V, von Wolff G, Clark K, Munzer P, et al. Antidepressants rescue stress-induced disruption of synaptic plasticity via serotonin transporter-independent inhibition of L-type calcium channels. Biol Psychiatry. 2018;84:55–64.
Google Scholar
Schoenfeld TJ, McCausland HC, Morris HD, Padmanaban V, Cameron HA. Stress and loss of adult neurogenesis differentially reduce hippocampal volume. Biol Psychiatry. 2017;82:914–23.
Google Scholar
McEwen BS, Gianaros PJ. Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Ann N Y Acad Sci. 2010;1186:190–222.
Google Scholar
Jackson SJ, Andrews N, Ball D, Bellantuono I, Gray J, Hachoumi L, et al. Does age matter? The impact of rodent age on study outcomes. Lab Anim. 2017;51:160–9.
Google Scholar
George B, Lumen A, Nguyen C, Wesley B, Wang J, Beitz J, et al. Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy. NPJ Syst Biol Appl. 2020;6:36.
Google Scholar
Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7:27–31.
Google Scholar
DeVane CL, Liston HL, Markowitz JS. Clinical pharmacokinetics of sertraline. Clin Pharmacokinet. 2002;41:1247–66.
Google Scholar
Kino T. Stress, glucocorticoid hormones, and hippocampal neural progenitor cells: implications to mood disorders. Front Physiol. 2015;6:230.
Google Scholar
Baudat M, de Kort AR, van den Hove DLA, Joosten EA. Early-life exposure to selective serotonin reuptake inhibitors: long-term effects on pain and affective comorbidities. Eur J Neurosci. 2022;55:295–317.
Google Scholar
Adriao A, Santana I, Ribeiro C, Cancela ML, Conceicao N, Grazina M. Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration. Neurol Sci. 2022;43:319–26.
Google Scholar
Aloni E, Oni-Biton E, Tsoory M, Moallem DH, Segal M. Synaptopodin deficiency ameliorates symptoms in the 3xTg mouse model of Alzheimer’s disease. J Neurosci. 2019;39:3983–92.
Google Scholar
Barker SJ, Raju RM, Milman NEP, Wang J, Davila-Velderrain J, Gunter-Rahman F, et al. MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration. Sci Transl Med. 2021;13:eabd7695.
Google Scholar
Ji C, Tang M, Zeidler C, Hohfeld J, Johnson GV. BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes. Autophagy. 2019;15:1199–213.
Google Scholar
Ren J, Zhang S, Wang X, Deng Y, Zhao Y, Xiao Y, et al. MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer’s disease in vivo and in vitro. Acta Biochim Biophys Sin (Shanghai). 2022;54:77–90.
Google Scholar
Sunderaraman P, Cosentino S, Schupf N, Manly J, Gu Y, Barral S. MEF2C common genetic variation is associated with different aspects of cognition in non-hispanic white and caribbean hispanic non-demented older adults. Front Genet. 2021;12:642327.
Google Scholar
Zhang Z, Zhao Y. Progress on the roles of MEF2C in neuropsychiatric diseases. Mol Brain. 2022;15:8.
Google Scholar
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018;50:668–81.
Google Scholar
Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, et al. Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. Nat Commun. 2018;9:1470.
Google Scholar
Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, et al. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet. 2016;48:1031–6.
Google Scholar
Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science. 2018;359:693–7.
Google Scholar
Weber MA, Kerr G, Thangavel R, Conlon MM, Gumusoglu SB, Gupta K, et al. Alpha-Synuclein Pre-Formed Fibrils Injected into Prefrontal Cortex Primarily Spread to Cortical and Subcortical Structures. J Parkinsons Dis. 2024;14:81–94.
Bertolli A, Halhouli O, Liu-Martinez Y, Blaine B, Thangavel R, Zhang Q et al. Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol that probes learning rate, retention and cognitive flexibility. bioRxiv [Preprint]. 2024 https://doi.org/10.1101/2024.11.30.625516.
Seno S, Tomura S, Miyazaki H, Sato S, Saitoh D. Effects of selective serotonin reuptake inhibitors on depression-like behavior in a laser-induced shock wave model. Front Neurol. 2021;12:602038.
Google Scholar
Mombereau C, Gur TL, Onksen J, Blendy JA. Differential effects of acute and repeated citalopram in mouse models of anxiety and depression. Int J Neuropsychopharmacol. 2010;13:321–34.
Google Scholar
Jacobsen JPR, Oh A, Bangle R, Roberts WL, Royer EL, Modesto N, et al. Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept. Neuropsychopharmacology. 2019;44:2082–90.
Google Scholar
Heinonen E, Blennow M, Blomdahl-Wetterholm M, Hovstadius M, Nasiell J, Pohanka A, et al. Sertraline concentrations in pregnant women are steady and the drug transfer to their infants is low. Eur J Clin Pharmacol. 2021;77:1323–31.
Google Scholar
Sit DK, Perel JM, Helsel JC, Wisner KL. Changes in antidepressant metabolism and dosing across pregnancy and early postpartum. J Clin Psychiatry. 2008;69:652–8.
Google Scholar
Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA. The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis. Expert Opin Drug Metab Toxicol. 2020;16:431–40.
Google Scholar
Stika CS, Wisner KL, George AL Jr., Avram MJ, Zumpf K, Rasmussen-Torvik LJ, et al. Changes in sertraline plasma concentrations across pregnancy and postpartum. Clin Pharmacol Ther. 2022;112:1280–90.
Google Scholar
Conti B, Maier R, Barr AM, Morale MC, Lu X, Sanna PP, et al. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. Mol Psychiatry. 2007;12:167–89.
Google Scholar
Rayan NA, Kumar V, Aow J, Rastegar N, Lim MGL, O’Toole N, et al. Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling. Mol Psychiatry. 2022;27:4510–25.
Google Scholar
Chaves T, Fazekas CL, Horvath K, Correia P, Szabo A, Torok B, et al. Stress adaptation and the brainstem with focus on corticotropin-releasing hormone. Int J Mol Sci. 2021;22:9090.
Google Scholar
Qiu J, Yao S, Hindmarch C, Antunes V, Paton J, Murphy D. Transcription factor expression in the hypothalamo-neurohypophyseal system of the dehydrated rat: upregulation of gonadotrophin inducible transcription factor 1 mRNA is mediated by cAMP-dependent protein kinase A. J Neurosci. 2007;27:2196–203.
Google Scholar
Shi Z, Pelletier NE, Wong J, Li B, Sdrulla AD, Madden CJ, et al. Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus. Elife. 2020;9:e55357.
Google Scholar
Kageyama K, Suda T. Regulatory mechanisms underlying corticotropin-releasing factor gene expression in the hypothalamus. Endocr J. 2009;56:335–44.
Google Scholar
Herman JP, Tasker JG. Paraventricular hypothalamic mechanisms of chronic stress adaptation. Front Endocrinol (Lausanne). 2016;7:137.
Google Scholar
Yuan PQ, Yang H. Neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexuses by insulin hypoglycemia. Am J Physiol Endocrinol Metab. 2002;283:E436–48.
Google Scholar
Jeong JK, Dow SA, Young CN. Sensory circumventricular organs, neuroendocrine control, and metabolic regulation. Metabolites. 2021;11:494.
Google Scholar
Croese T, Ramos, JM, Castellani, G, Ferrera, S, Tzipora, FZ, Judith, AP, and Schwartz, M Pregnancy exacerbates early-onset familial Alzheimer’s disease. Neurology 2021;96:4075.
Cummings M, Arumanayagam ACS, Zhao P, Kannanganat S, Stuve O, Karandikar NJ, et al. Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis. PLoS One. 2018;13:e0200752.
Google Scholar
Li XY, Wang F, Chen GH, Li XW, Yang QG, Cao L, et al. Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice. Age (Dordr). 2016;38:59.
Google Scholar
Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology. 2008;33:88–109.
Google Scholar
Johansen A, Armand S, Plaven-Sigray P, Nasser A, Ozenne B, Petersen IN, et al. Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial. Mol Psychiatry. 2023;28:4272–9.
Google Scholar
Duan W, Peng Q, Masuda N, Ford E, Tryggestad E, Ladenheim B, et al. Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington’s disease. Neurobiol Dis. 2008;30:312–22.
Google Scholar
Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron. 2008;58:571–83.
Google Scholar
Spilker C, Grochowska KM, Kreutz MR. What do we learn from the murine Jacob/Nsmf gene knockout for human disease? Rare Dis. 2016;4:e1241361.
Google Scholar
Wegener S, Buschler A, Stempel AV, Kang SJ, Lim CS, Kaang BK, et al. Defective synapse maturation and enhanced synaptic plasticity in Shank2 Deltaex7(-/-) Mice. eNeuro. 2018;5:ENEURO.0398-17.2018.
Google Scholar
Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci. 2017;18:147–57.
Google Scholar
Barbosa AC, Kim MS, Ertunc M, Adachi M, Nelson ED, McAnally J, et al. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci USA. 2008;105:9391–6.
Google Scholar
Farsi Z, Nicolella A, Simmons SK, Aryal S, Shepard N, Brenner K, et al. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023;111:3378–96.e3379.
Google Scholar
Ammari R, Monaca F, Cao M, Nassar E, Wai P, Del Grosso NA, et al. Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy. Science. 2023;382:76–81.
Google Scholar
Chan RW, Ho LC, Zhou IY, Gao PP, Chan KC, Wu EX. Structural and functional brain remodeling during pregnancy with diffusion tensor MRI and resting-state functional MRI. PLoS One. 2015;10:e0144328.
Google Scholar
Hillerer KM, Jacobs VR, Fischer T, Aigner L. The maternal brain: an organ with peripartal plasticity. Neural Plast. 2014;2014:574159.
Google Scholar
Zhou R, Liu HM, Zou LW, Wei HX, Huang YN, Zhong Q, et al. Associations of parity with change in global cognition and incident cognitive impairment in older women. Front Aging Neurosci. 2022;14:864128.
Google Scholar
Bartels C, Wagner M, Wolfsgruber S, Ehrenreich H, Schneider A. Alzheimer’s disease neuroimaging I. Impact of SSRI therapy on risk of conversion from mild cognitive impairment to Alzheimer’s dementia in individuals with previous depression. Am J Psychiatry. 2018;175:232–41.
Google Scholar
Rajkumar R. Resolving a paradox: antidepressants, neuroinflammation, and neurodegeneration. Explor Neuroprot Ther. 2024;4:11–37.
Reed MB, Vanicek T, Seiger R, Klobl M, Spurny B, Handschuh P, et al. Neuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval. Neuroimage. 2021;236:118039.
Google Scholar
Sun DS, Gao LF, Jin L, Wu H, Wang Q, Zhou Y, et al. Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3xTgAD mice. Neuropharmacology. 2017;126:200–12.
Google Scholar
Castagne V, Moser P, Roux S, Porsolt RD Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Neurosci 2011; Ch. 8: Unit 8.10A.
Sensini F, Inta D, Palme R, Brandwein C, Pfeiffer N, Riva MA, et al. The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific. Sci Rep. 2020;10:17281.
Google Scholar
Clarkson JM, Dwyer DM, Flecknell PA, Leach MC, Rowe C. Handling method alters the hedonic value of reward in laboratory mice. Sci Rep. 2018;8:2448.
Google Scholar
Ueno H, Takahashi Y, Suemitsu S, Murakami S, Kitamura N, Wani K, et al. Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results. Sci Rep. 2020;10:3509.
Google Scholar
Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39:112–9.
Google Scholar
Gumusoglu SB, Maurer SV, Stevens HE. Dataset describing maternal prenatal restraint stress effects on immune factors in mice. Data Brief. 2022;43:108348.
Google Scholar
Gumusoglu S, Scroggins S, Vignato J, Santillan D, Santillan M. The serotonin-immune axis in preeclampsia. Curr Hypertens Rep. 2021;23:37.
Google Scholar
Gumusoglu S, Meincke CR, Kiel M, Betz A, Nuckols V, DuBose L, et al. Low indoleamine 2, 3 dioxygenase (IDO) activity is associated with psycho-obstetric risk. Pregnancy Hypertens. 2024;35:12–8.
Google Scholar
Mertens M Protect Pregnant Women ‘Through Research,’ Not ‘From Research,’ OB-GYNs Urge. npr.: Shots Health News From NPR, 2021.
Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, et al. Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Transl Psychiatry. 2021;11:79.
Google Scholar
Zoega H, Kieler H, Norgaard M, Furu K, Valdimarsdottir U, Brandt L, et al. Use of SSRI and SNRI Antidepressants during Pregnancy: A Population-Based Study from Denmark, Iceland, Norway and Sweden. PLoS One. 2015;10:e0144474.
Google Scholar
Wikman A, Skalkidou A, Wikstrom AK, Lampa E, Kramer MS, Yong EL, et al. Factors associated with re-initiation of antidepressant treatment following discontinuation during pregnancy: a register-based cohort study. Arch Womens Ment Health. 2020;23:709–17.
Google Scholar
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